P03-016 - ANTI IL1 refractory CINCA respondes to ANTI IL6
نویسندگان
چکیده
منابع مشابه
P03-016 - ANTI IL1 refractory CINCA respondes to ANTI IL6
Case Report A 13 year old boy from a healthy non-consanguineous family suffers from severe autoinflammatory symptoms (persistent fever, polyserositis, urticaria, arthritis, developmental delay, deafness and hepatosplenomegaly) since his first year of life. Based on clinical presentation and genotype (heterozygous mutation (CAG)>Lysin (AAG)-p. Gln703Lys/Q705K substitution in Exon 3 of NLPR3) he ...
متن کاملAnti-IL1 therapy in patients with refractory FMF living inGermany
Results Within our cohort of 160 adult patients with FMF, we identified 15 patients (4 female and 11 male) who were treated with anakinra (n=13) or canakinumab (n=2). Twelve of 15 patients (80%) were of turkish-armenian ancestry. The median FMF severity score was 8 (range 5-14). Patients carrying two high-penetrance MEFV mutations (M694V or M680I) had a severity score of 9 (8/15=53%). Patients ...
متن کاملResistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade.
Anti-VEGF therapies benefit several cancer types, but drug resistance that limits therapeutic response can emerge. We generated cell lines from anti-VEGF-resistant tumor xenografts to investigate the mechanisms by which resistance develops. Of all tumor cells tested, only A431 (A431-V) epidermoid carcinoma cells developed partial resistance to the VEGF inhibitor aflibercept. Compared with the p...
متن کاملGene expression in active systemic JIA after anti-IL1 and anti-IL6R treatment
Introduction We have previously found specific genes upregulated in PBMCs of active sJIA [1]. Biologics to block IL-1 and IL-6 signalling have both been shown to be effective in early clinical trials. In this study we examine the expression before and after anti-IL1 and anti IL-6R treatment in PBMCs and their constitutive cell types; using gene expression analysis to further understand the dise...
متن کاملP02-020 - CAPS in Turkish children: treatment with ANTI IL1
Case Report Results All of our patients had symptoms within the first 3 months of life. All had fever, urticaria and persistant labaratory inflammation. All except one patient had failure to thrive. Except for the one patient with Muckle Wells syndrome all had neurological features ranging from headache to convulsions, hydrocephalus, cognitive dysfunction.Two patients, one without a mutation, h...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s1-a214